Wentz had his best year(s) in Philly when Frank Reich was his OC. My understanding was that they had a strong relationship.
So maybe Reich knows how to push the right buttons with Wentz. Only time will tell, and I won't make any predictions.
But I do know a couple things that set Indy apart from Philly over the last couple of years:
Indy's OL is far-far superior to Philly OL. So Wentz won't be running for his life all the time when he drops back to pass.
Indy has better WR's and depth than Philly has had.
Indy has a very good/great running game (again, props to OL), whereas Philly had practically zilch.
Indy is as close to the perfect landing spot, for Wentz, that you could find.
If he doesn't succeed in Indy, then it's all on Wentz.